DELETED: Occupational toxicologyLaajuus (3 cr)

Objective

- Explain importance of exposure and different exposure routes in occupational context. - Describe the various possibilities to assess the exposure in occupational context, and the uncertainties related to the different approaches (measurements, modelling) to assess the exposure. - Describe the possibilities to control exposure in occupational context, and the uncertainties related to the control of exposure. - Explain the principles of occupational exposure limit values (OELs) and other limit values given for occupational exposure (e.g. REACH worker-DNELs). - Describe toxic effects of most relevant toxic compounds including nanoparticles in occupational environment. - Name the most common occupational diseases. - Explain the concept of biomonitoring and the use of biomarkers in the exposure and health surveillance. - Recognize the uncertainties and ethical aspects related to the use of biomonitoring. - List examples on interactions of chemicals and chemicals and noise. - Define specific measures set to protect workers and their offspring from the reprotoxic, genotoxic and carcinogenic effects of occupational exposures. - Recognize the role of the Finnish Institute of Occupational Health in occupational safety assessment.

Qualifications

Basics of pharmacology and toxicology, anatomy and physiology, environmental sciences or equivalent knowledge.

Materials

Klaassen CD: Casarett & Doulls Toxicology, The Basic Science of Poisons (latest edition) (McGraw-Hill). Winder C and Stacey NH: Occupational Toxicology, 2nd Edition. Selected scientific articles and indicated websites. Other distributed material.

Further information

Time: Spring term Offering data: TOX, PR4-5, PhD-students Contact person: Heidi Sahlman, heidi.sahlman(at)uef.fi Office: Maiju Laitinen, maiju.laitinen(at)uef.fi

Execution methods

Blended teaching, lectures, assignments in Moodle, laboratory visit, independent studying.

Accomplishment methods

Assignments in Moodle Evaluation criteria: Pass-Fail