DELETED: Neuropharmacology and neural drug targetsLaajuus (5 cr)

Objective

After the course, the student is able to: - Describe the key neurotransmitter systems and modulation of their activity - Describe neural key drug targets in the CNS and how drugs can modulate the activity of neural networks - Explain how brain disorders affect to neural networks - Explain the mechanism of action of certain neurotoxins Generic skills: internationality, critical thinking, identification and development of expertise, interaction and communication

Content

- Cellular basis of communication, fundamentals of neuropharmacology - Neurotransmitter systems and neural substrates of drug action in the CNS - Neurodegeneration - Neuropharmacology of neural systems and the most common brain disorders - Examples of neurotoxins and their mechanisms of action

Qualifications

Basic pharmacology (PEFA) and Systematic Pharmacology 1 (SYFA1) or corresponding skills in basic pharmacology and toxicology

Materials

Textbook: Nestler, Hyman & Malenka’s Molecular Neuropharmacology: A Foundation for Clinical Neuroscience, 4th edition, McGrawHill, 2020 Other material: Selected review articles

Further information

Offering data: PR4-5 (PR3), TOX, PhD students, Exchange students in Pharmacy. Course has a maximum of 40 students, UEF pharmacy students having pharmacology or drug toxicology as their main subject will be have the first priority. Time: Autumn semester Campus: Kuopio Contact information: - Course director Markus Forsberg, markus.forsberg(at)uef.fi - Office Maiju Laitinen, maiju.laitinen(at)uef.fi Keywords: Neurotransmitters, neuropharmacology, brain disorders, neurotoxins Course includes the elements of sustainable development (i.e., health, ethics)

Execution methods

Contact teaching: - Lectures as a contact teaching (part of lectures online) - Preparation of seminar presentation as a pair work - Seminars as a contact teaching (participation online possible) - Independent studying (textbook, selected material)

Accomplishment methods

Study methods: Participation to teaching, seminar presentation, opponent task, exam: lectures 30 h, compulsory seminar presentation (pair work) 16 h, compulsory seminars 10 h (attendance 75 %), opponent task 2 h, exam 3 h, independent studying 84 h Evaluation criteria: Compulsory seminar presentation (passed-failed), participation in seminars (attendance 75 %), opponent task, exam (grade F-5).